000 03124nmm a22003495i 4500
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008 100301s2005 xxu| s |||| 0|eng d
020 _a9780387239231
_9978-0-387-23923-1
082 _a612.8
_223
245 _aNeurodegeneration and Prion Disease
_h[electronic resource] /
_cedited by David R. Brown.
250 _a1st ed. 2005.
260 _aNew York, NY :
_bSpringer US :
_bImprint: Springer,
_c2005.
300 _aXV, 473 p.
_bonline resource.
505 _aNeuropathology of Transmissible Spongiform Encephalopathies (Prion Diseases) -- Central Pathogenesis of Prion Diseases -- Hereditary Prion Protein Amyloidoses -- Mouse Behavioural Studies and What They Can Teach Us about Prion Diseases -- Electrophysiological Approaches to the Study of Prion Diseases -- Prion Protein, Prion Protein-Like Protein, and Neurodegeneration -- Oxidative Stress and Mitochondrial Dysfunction in Neurodegeneration of Transmissible Spongiform Encephalopathies (TSEs) -- Mechanisms of Prion Toxicity and Their Relationship to Prion Infectivity -- A Stone Guest on the Brain: Death as a Prion -- Molecular Mechanisms Mediating Neuronal Cell Death in Experimental Models of Prion Diseases, in vitro -- Processing and Mis-Processing of the Prion Protein: Insights into the Pathogenesis of Familial Prion Disorders -- Signaling Pathways Controling Prion Neurotoxicity: Role of Endoplasmic Reticulum Stress-Mediated Apoptosis -- Cell Culture Models to Unravel Prion Protein Function and Aberrancies in TSE -- Insights into the Cellular Trafficking of Prion Proteins -- The Molecular Basis of Prion Protein-Mediated Neuronal Damage -- Conclusion: Intervention, the Final Frontier.
520 _aThis volume provides an in-depth overview from world experts on prion disease. These fatal diseases include Creutzfeldt-Jakob disease, chronic wasting disease in deer, scrapie of sheep, bovine spongiform encephalopathy (mad cow's disease) of cattle and related diseases. Understanding what causes neuronal death in these diseases is essential to both preventing and curing them. The most recent advances in understanding neuronal death in prion diseases are presented. Prion diseases serve as an experimental model for all neurodegenerative conditions. This book will provide understanding of neurodegeneration and provide an up-to-date record of the state of the art for other specialists and non-specialists in related fields.
650 _aNeurosciences.
_920502
650 _aBiomathematics.
_920503
650 _aNeurology .
_920504
650 _aBiochemistry.
_920505
650 _aVeterinary medicine.
_920506
650 _aMedicine-Research.
_920507
650 _aBiology-Research.
_920508
650 _aNeuroscience.
_920509
650 _aMathematical and Computational Biology.
_920510
650 _aNeurology.
_920504
650 _aBiochemistry.
_920505
650 _aVeterinary Science.
_920511
650 _aBiomedical Research.
_920512
700 _aBrown, David R.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
_920513
856 _uhttps://doi.org/10.1007/b103635
942 _cEBK
999 _c13648
_d13648