Engineering Multifunctional Niosomes Loaded with Plasmonic Gold Nanorod for Cancer Phototheranostics (Record no. 16598)

MARC details
000 -LEADER
fixed length control field 02434nam a22001937a 4500
082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER
Classification number 615.19
Item number P954E
100 ## - MAIN ENTRY--AUTHOR NAME
Personal name Prince, Yumnam
245 ## - TITLE STATEMENT
Title Engineering Multifunctional Niosomes Loaded with Plasmonic Gold Nanorod for Cancer Phototheranostics
Statement of responsibility, etc by Yumnam Prince
260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT)
Place of publication IIT Jodhpur
Name of publisher Department of Bioscience and Bioengineering
Year of publication 2023
300 ## - PHYSICAL DESCRIPTION
Number of Pages vi,28p.
Other physical details HB
500 ## - GENERAL NOTE
General note Light-mediated theranostic platforms involve the use of agents (small molecules/nanomaterials) that can absorb light to produce heat or reactive chemical species (RCS), as well as emit fluorescence. These platforms are advantageous in personalized medicine, offering enhanced diagnostic capabilities, improved therapeutic efficiencies, and the ability to monitor treatment outcomes using imaging modalities. Agents that absorb near-infrared (NIR) light provide minimal scattering, low autofluorescence, superior spatio-temporal resolution, and deeper tissue penetration depths. Gold nanorods (GNR) and indocyanine green (ICG) are two such agents known for their NIR light absorption properties. GNR offers tunable plasmonic properties, while ICG is an FDA-approved NIR fluorophore.<br/><br/>However, the use of ICG and GNR is hampered by various limitations, including photobleaching, non-specificity, toxicity, and aggregation in solution. To overcome these challenges, we present NIR light-activatable niosomes loaded with GNR and ICG for cancer theranostic applications. Both agents were encapsulated into biocompatible niosomes based on non-ionic surfactants to form ICG-GNR@Nio, achieving superior loading efficiencies and enhanced properties. ICG-GNR@Nio exhibits excellent storage stability, photostability, elevated temperature rise, and generation of reactive oxygen species (ROS) upon 1064 nm laser irradiation.<br/><br/>Subsequently, the enhanced phototherapeutic capabilities of ICG-GNR@Nio were validated in in vitro cellular experiments. Overall, ICG-GNR@Nio-based theranostic platforms represent a significant advancement in improving diagnosis and therapeutic capabilities for biomedical clinicians in combating various diseases.
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical Term Department of Bioscience and Bioengineering
Topical Term Near-Infrared (NIR) Absorption Agents
Topical Term Niosomes in Drug Delivery
Topical Term Cancer Theranostics
Topical Term MTech Theses
700 ## - ADDED ENTRY--PERSONAL NAME
Personal name Vankayala, Raviraj
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Koha item type Thesis
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Withdrawn status Lost status Damaged status Not for loan Collection code Permanent Location Current Location Shelving location Date acquired Source of acquisition Full call number Accession Number Price effective from Koha item type
        Theses S. R. Ranganathan Learning Hub S. R. Ranganathan Learning Hub Reference 2024-04-01 Office of Academics 615.19 P954E TM00534 2024-07-01 Thesis