Gene Transfer and the Ethics of First-in-Human Research (Record no. 13137)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02170nam a2200169 4500 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| ISBN | 9780521690843 |
| 082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 615.895 |
| Item number | K571G |
| 100 ## - MAIN ENTRY--AUTHOR NAME | |
| Personal name | Kimmelman, Jonathan. |
| 245 ## - TITLE STATEMENT | |
| Title | Gene Transfer and the Ethics of First-in-Human Research |
| Sub Title | Lost in translation |
| Statement of responsibility, etc | by Jonathan Kimmelman. |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) | |
| Place of publication | Cambridge, UK |
| Name of publisher | Cambridge University Press |
| Year of publication | 2010. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Number of Pages | xi, 205 p. |
| Other physical details | ill.,24 cm. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE | |
| Bibliography, etc | Includes bibliographical references and index. |
| 505 ## - FORMATTED CONTENTS NOTE | |
| Formatted contents note | Introduction: gene transfer lost in translation -- What is gene transfer? -- Safety, values, and legitimacy: the protean nature of risk in translational trials -- Taming uncertainty: risk and gene-transfer clinical research -- Succor or suckers? Benefit, risk, and the therapeutic misconception -- Looking backward: a model value for translational trials -- The chasm: the ethics of initiating first-in-human clinical trials -- Tropic of cancers: gene transfer in resource-poor settings -- Great expectations and hard times: expectation management in gene transfer -- Something in the sight adjusts itself: conclusions. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc | "Human gene transfer is widely regarded as one of the most promising technologies for the treatment of a variety of disorders, but it presents practitioners with a variety of difficult ethical questions. Gene Transfer and the Ethics of First-in-Human Research examines the ethical and policy dimensions of testing interventions in human beings for the first time. The book discusses the difficult ethical challenges that arise from attempting to translate laboratory discoveries into clinical applications. These range from which available techniques to use, when to initiate human testing, questions of consent, expectation in public arenas, how to define acceptable risk, and the inclusion of vulnerable or disadvantaged subjects in early phase trials. This book is relevant to ethicists, legal practitioners, policy makers, geneticists and clinicians involved in clinical trials of new medical interventions"--Provided by publisher. |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical Term | Gene therapy |
| -- | Clinical trials |
| -- | Gene Transfer Techniques |
| -- | Human Experimentation |
| -- | Public Policy. |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Koha item type | Book |
| Withdrawn status | Lost status | Damaged status | Not for loan | Permanent Location | Current Location | Shelving location | Date acquired | Full call number | Accession Number | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|
| S. R. Ranganathan Learning Hub | S. R. Ranganathan Learning Hub | 2023-06-17 | 615.895 K571G | 09177 | 2023-06-17 | Book | |||||
| S. R. Ranganathan Learning Hub | S. R. Ranganathan Learning Hub | 2023-06-17 | 615.895 K571G | 09178 | 2023-06-17 | Book |